Oxycontin
$400.00
Description
OxyContin, a trade name for the narcotic oxycodone hydrochloride, is a painkiller available in the United States only by prescription. OxyContin is legitimately prescribed for relief of moderate to severe pain resulting from injuries, bursitis, neuralgia, arthritis, and cancer.
Oxycodone, sold under the brand name Roxicodone and OxyContin(which is the extended-release form) among others, is a semi-synthetic opioid used medically for the treatment of moderate to severe pain. It is highly addictive[14] and is a commonly abused drug.[15][16] It is usually taken by mouth, and is available in immediate-releaseand controlled-release formulations.[15]Onset of pain relief typically begins within fifteen minutes and lasts for up to six hours with the immediate-release formulation.[15] In the United Kingdom, it is available by injection.[17] Combination products are also available with paracetamol (acetaminophen), ibuprofen, naloxone, naltrexone, and aspirin.[15]
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| Pronunciation | /ɒksiˈkoʊdoʊn/ |
| Trade names | Roxicodone, OxyContin, others |
| Other names | Eukodal, eucodal; dihydrohydroxycodeinone, 7,8-dihydro-14-hydroxycodeinone, 6-deoxy-7,8-dihydro-14-hydroxy-3-O-methyl-6-oxomorphine[1] |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a682132 |
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| Dependence liability |
High[3] |
| Addiction liability |
High[4] |
| Routes of administration |
By mouth, sublingual, intramuscular, intravenous, intranasal, subcutaneous, transdermal, rectal, epidural[5] |
| Drug class | Opioid |
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| Pharmacokinetic data | |
| Bioavailability | By mouth: 60–87%[7][8] |
| Protein binding | 45%[7] |
| Metabolism | Liver: mainly CYP3A, and, to a much lesser extent, CYP2D6 (~5%);[7]95% metabolized (i.e., 5% excreted unchanged)[10] |
| Metabolites | • Noroxycodone(25%)[9][10] • Noroxymorphone(15%, free and conjugated)[9][10] • Oxymorphone(11%, conjugated)[9][10] • Others (e.g., minor metabolites)[10] |
| Onset of action | IRTooltip Instant release: 10–30 minutes[8][10] CRTooltip controlled release: 1 hour[11] |
| Elimination half-life | IR: 2–3 hours[10][8] CR: 4.5 hours[12] |
| Duration of action | IR: 3–6 hours[10] CR: 10–12 hours[13] |
| Excretion | Urine (83%)[7] |
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| ECHA InfoCard | 100.000.874 |
| Chemical and physical data | |
| Formula | C18H21NO4 |
| Molar mass | 315.369 g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 219 °C (426 °F) |
| Solubility in water | 166 (HCl) |
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Common side effects include euphoria, constipation, nausea, vomiting, loss of appetite, drowsiness, dizziness, itching, dry mouth, and sweating.[15] Side effects may also include addiction and dependence, substance abuse, irritability, depression or mania, delirium, hallucinations, hypoventilation, gastroparesis, bradycardia, and hypotension.[15] Those allergic to codeine may also be allergic to oxycodone.[15] Use of oxycodone in early pregnancy appears relatively safe.[15] Opioid withdrawal may occur if rapidly stopped.[15] Oxycodone acts by activating the μ-opioid receptor.[18]When taken by mouth, it has roughly 1.5 times the effect of the equivalent amount of morphine.[19]
Oxycodone was originally produced from the opium poppy opiate alkaloid thebaine in 1916 in Germany. One year later, it was used medically for the first time in Germany in 1917.[20] It is on the World Health Organization’s List of Essential Medicines.[21] It is available as a generic medication.[15] In 2022, it was the 60th most commonly prescribed medication in the United States, with more than 11 million prescriptions.[22][23] A number of abuse-deterrent formulations are available, such as in combination with naloxone or naltrexone.[16][24]
Arlen P –
After years of dealing with nerve pain, OxyContin is the only thing that truly helps. The relief is consistent and the delivery was discreet and fast.
Maila D –
Excellent service. My prescription was handled professionally and arrived within two days. OxyContin helps me get through the day without constant pain.
Aberdeen –
Chronic back pain used to ruin my sleep. This gives me the relief I need to function. Delivery was secure and packaging was subtle.
Ronan –
I’ve tried everything for my arthritis, but only OxyContin brings me full relief. Service was prompt, and I appreciated the follow-up support
Zayven –
Effective for long-term injury recovery. Pain levels are finally under control. Easy to order and arrived earlier than expected.
Daxon –
The only medication that keeps my pain from surgery in check. Delivery came quickly with clear instructions. Thank you.
Milton keynes –
Was worried about getting my prescription filled smoothly, but everything went perfectly. Medication works well and lasts as expected.
Elani –
OxyContin helps manage my pain with fewer doses. Ordering online was straightforward, and they were very professional throughout.
K Sunderland –
I suffer from post-accident trauma pain, and this gives me real relief. Very reliable delivery service—never late.
Liora –
I was treated with respect throughout the process. OxyContin is strong but effective when taken as prescribed. Highly recommended for chronic pain sufferers.