What is the most important information I should know about Saxenda^®?

Serious side effects may happen in people who take Saxenda^®, including:

Possible thyroid tumors, including cancer. Tell your health care professional if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rats and mice, Saxenda^® and medicines that work like Saxenda^® caused thyroid tumors, including thyroid cancer. It is not known if Saxenda^® will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people.

Do not use Saxenda^® if you or any of your family have ever had MTC, or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).

Who should not use Saxenda^®?

Do not use Saxenda^® if:

• you or any of your family have ever had MTC or if you have MEN 2
• you have had a serious allergic reaction to liraglutide or any of the ingredients in Saxenda^®. See symptoms of serious allergic reactions in “What are the possible side effects of Saxenda^®?”

Before taking Saxenda^®, tell your health care provider about all of your medical conditions, including if you:

• have or have had problems with your pancreas
• have severe problems with your stomach, such as slowed emptying of your stomach (gastroparesis) or problems with digesting food
• are scheduled to have surgery or other procedures that use anesthesia or deep sleepiness (deep sedation)
• have or have had depression or suicidal thoughts, or mental health issues
• are breastfeeding or plan to breastfeed. It is not known if Saxenda^® passes into your breast milk. You and your health care provider should decide if you will use Saxenda^® or breastfeed

Tell your health care provider about all the medicines you take, including prescription, over-the-counter medicines, vitamins, and herbal supplements. Saxenda^® may affect the way some medicines work and some other medicines may affect the way Saxenda^® works. Tell your health care provider if you take diabetes medicines, especially insulin and sulfonylurea medicines.

How should I use Saxenda^®?

• Read the Instructions for Use that comes with Saxenda^®
• Inject your dose of Saxenda^® under the skin (subcutaneously) in your stomach area (abdomen), upper leg (thigh), or upper arm, as instructed by your health care provider. Do not inject into a vein or muscle
• Saxenda^® is injected 1 time each day, at any time during the day.
• Change (rotate) your injection site within the area you choose with each injection to reduce your risk of getting lumps under the skin (cutaneous amyloidosis). Do not use the same site for each injection
• Do not share your SAXENDA^® pen with other people, even if the needle has been changed. You may give other people a serious infection or get a serious infection from them.

What are the possible side effects of Saxenda^®?

Saxenda^® may cause serious side effects, including:

• inflammation of the pancreas (pancreatitis). Stop using Saxenda^® and call your healthcare provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without vomiting. You may feel the pain from your stomach area (abdomen) to your back
• increased risk of low blood sugar (hypoglycemia) in adults with type 2 diabetes especially those who also take medicines to treat type 2 diabetes such as sulfonylureas or insulin
• risk of low blood sugar (hypoglycemia) in children who are 12 years of age and older without type 2 diabetes. Signs and symptoms of low blood sugar may include: dizziness or light-headedness, blurred vision, anxiety, irritability or mood changes, sweating, slurred speech, hunger, confusion or drowsiness, shakiness, weakness, headache, fast heartbeat, and feeling jittery. You should check your blood sugar before you start taking Saxenda^® and while you take Saxenda^®
• increased heart rate. Saxenda^® can increase your heart rate while you are at rest. Your health care provider should check your heart rate while you take Saxenda^®. Tell your health care professional if you feel your heart racing or pounding in your chest and it lasts for several minutes
• dehydration leading to kidney problems. Diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration) which may cause kidney problems. It is important for you to drink fluids to help reduce your chance of dehydration. Tell your healthcare provider right away if you have nausea, vomiting, or diarrhea that does not go away
• severe stomach problems. Stomach problems, sometimes severe, have been reported in people who use Saxenda^®. Tell your healthcare provider if you have stomach problems that are severe or will not go away
• serious allergic reactions. Stop using Saxenda^® and get medical help right away if you have any symptoms of a serious allergic reaction including swelling of your face, lips, tongue, or throat, fainting or feeling dizzy, very rapid heartbeat, problems breathing or swallowing, or severe rash or itching
• gallbladder problems. Saxenda^® may cause gallbladder problems including gallstones. Some gallbladder problems need surgery. Call your healthcare provider if you have any of the following symptoms: pain in your upper stomach (abdomen), fever, yellowing of your skin or eyes (jaundice), or clay-colored stools
• depression or thoughts of suicide. You should pay attention to any mental changes, especially sudden changes, in your mood, behaviors, thoughts, or feelings. Call your health care provider right away if you have any mental changes that are new, worse, or worry you
• food or liquid getting into the lungs during surgery or other procedures that use anesthesia or deep sleepiness (deep sedation). Saxenda^® may increase the chance of food getting into your lungs during surgery or other procedures. Tell all your healthcare providers that you are taking Saxenda^® before you are scheduled to have surgery or other procedures

The most common side effects of Saxenda^® in adults include nausea, diarrhea, constipation, vomiting, injection site reaction, low blood sugar (hypoglycemia), headache, tiredness (fatigue), dizziness, stomach pain, and change in enzyme (lipase) levels in your blood. Additional common side effects in children are fever and gastroenteritis.