Sibutramine
$210.00
Description
| Learn more
This article needs additional citations for verification. (March 2025)
|
Sibutramine, formerly sold under the brand name Meridia among others, is an appetite suppressant which has been discontinued in many countries. It works as a serotonin–norepinephrine reuptake inhibitor (SNRI) similar to certain antidepressants. Until 2010, it was widely marketed and prescribed as an adjunct in the treatment of obesityalong with diet and exercise. It has been associated with increased cardiovascular diseases and strokesand has been withdrawn from the market in 2010 in several countries and regions including Australia,[2] Canada,[3] China,[4] the European Union,[5]Hong Kong,[6] India,[7] Mexico, New Zealand,[8] the Philippines,[9] Thailand,[10] the United Kingdom,[11] and the United States.[12] It was never approved in Japan.[13] However, the drug remains available in some countries.[14]
 |
|
Sibutramine (top),
(S)-(−)-sibutramine (bottom) |
|
| Clinical data | |
|---|---|
| Trade names | Meridia, others |
| Other names | BTS-54524 |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a601110 |
| Pregnancy category |
|
| Routes of administration |
By mouth |
| Drug class | Serotonin–norepinephrine reuptake inhibitor; Anoretic |
| ATC code | |
| Legal status | |
| Legal status |
|
| Pharmacokinetic data | |
| Bioavailability | Absorption 77%, considerable first-pass metabolism |
| Protein binding | 97%, (94% for its desmethyl metabolites, M1 & M2) |
| Metabolism | Hepatic (CYP3A4-mediated) |
| Elimination half-life | 1 hour (sibutramine), 14 hours (M1) & 16 hours (M2) |
| Excretion | Urine (77%), feces (8%) |
| Identifiers | |
| CAS Number |
|
| PubChem CID | |
| IUPHAR/BPS | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.130.097 |
| Chemical and physical data | |
| Formula | C17H26ClN |
| Molar mass | 279.85 g·mol−1 |
| 3D model (JSmol) | |
| (verify) | |
Sibutramine was originally developed in 1988 by Boots in Nottingham, UK,[15]and manufactured and marketed by Abbott Laboratories and sold under a variety of brand names including Reductil, Meridia, Siredia, and Sibutrex before its withdrawal 2010 from most markets. It was classified as a Schedule IV controlled substance in the United States.
As of 2018, the US Food and Drug Administration (FDA) still found sibutramine in over 700 diet supplements marketed as “natural”, “traditional”, or “herbal remedies”.[citation needed]
Miro Z –
Super fast delivery! Ordered on a Monday and had it by Wednesday. Sibutramine worked great — I wasn’t even thinking about food all day. Honestly, for the price, I didn’t expect such solid results. Will be reordering soon!
Indira Rae –
Affordable and effective, which is rare these days. Customer service was kind and responded fast when I had questions. Been using it for two weeks and already feel lighter and more focused. No regrets!
Cael Noah –
The service was smooth and professional. Got my package quickly and discreetly. Sibutramine helped me drop 5kg in under a month — I didn’t even feel like I was dieting. Honestly a steal for what it does.
Tahlia B –
I’m impressed with how fast it arrived — wasn’t expecting it that quick! Price was way better than what I saw on other sites, and the appetite suppression kicked in on day two. It’s been a blessing for my routine.
Orion Jett –
Sibutramine gave me consistent results and the service behind it was top-notch. Affordable, clear instructions, and no weird charges or delays. Lost 4kg so far without changing my lifestyle too much
Nayomi S –
Great experience all around! It arrived earlier than expected and customer support answered all my concerns with patience. I love how affordable it is — most weight loss stuff costs way more and delivers way less.